2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W752476
    Succinyladenosine-13C4 1923744-27-7 98%
    Succinyladenosine-13C4 (N6-Succinyl adenosine-13C4) is the 13C-labeled Succinyladenosine (HY-113284). Succinyladenosine, the metabolic product of dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase, is a biochemical marker of adenylosuccinase (ASL) deficiency.
    Succinyladenosine-13C4
  • HY-W752616
    1-Aminopropan-2-ol-d6 1219795-13-7 98%
    1-Aminopropan-2-ol-d6 (Monoisopropanolamine-d6) is the deuterium labeled 1-Aminopropan-2-ol (HY-W015969). 1-Aminopropan-2-ol is a microbial metabolism of amino alcohol metabolism via propionaldehyde and acetaldehyde in a species of Pseudomonas.
    1-Aminopropan-2-ol-d6
  • HY-W753181
    (S)-2-Hydroxy-3-phenylpropanoic acid-13C9 98%
    (S)-2-Hydroxy-3-phenylpropanoic acid-13C9 (L-(-)-3-Phenyllactic Acid-13C9) is the 13C-labeled (S)-2-Hydroxy-3-phenylpropanoic acid (HY-30220). (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria.
    (S)-2-Hydroxy-3-phenylpropanoic acid-13C9
  • HY-W753207
    Porphobilinogen-13C2,15N 98%
    Porphobilinogen-13C2,15N is the 13C- and 15N-labeled Porphobilinogen (HY-W013495). Porphobilinogen could act as a phototoxin, a neurotoxin, and a metabotoxin.
    Porphobilinogen-13C2,15N
  • HY-W753452
    N,N-Dimethyltryptamine N-oxide-d6 98%
    N,N-Dimethyltryptamine N-oxide-d6 is the deuterium labeled N,N-Dimethyltryptamine N-oxide (HY-W576312). N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide-d6
  • HY-W753593
    N4-Acetylcytidine-13C5 98%
    N4-Acetylcytidine-13C5 is the 13C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity.
    N4-Acetylcytidine-13C5
  • HY-W753671
    2,6-Diaminoheptanedioic acid-13C7 1485529-87-0 98%
    2,6-Diaminoheptanedioic Acid-13C7 is a 13C7 labeled version of 2,6-Diaminoheptanedioic acid (HY-128746). 2,6-Diaminoheptanedioic acid is an endogenous metabolite.
    2,6-Diaminoheptanedioic acid-13C7
  • HY-W753983
    Pyruvic acid-13C3 378785-77-4 98%
    Pyruvic acid-13C is isotype-labeled compound of Pyruvic acid. Pyruvic acid is an intermediate metabolite in the metabolism of carbohydrates, proteins, and fats.
    Pyruvic acid-13C3
  • HY-W754054
    Propionylglycine (Standard)-13C2,15N 98%
    Propionylglycine (Standard)-13C2,15N is the 13C- and 15N-labeled Propionylglycine (HY-W587803). Propionylglycine is a peptide.
    Propionylglycine (Standard)-13C2,15N
  • HY-W754064
    Cytidine-5'-triphosphate-13C5 200258-75-9 98%
    Cytidine-5'-triphosphate-13C5 (Cytidine triphosphate-13C5) is the 13C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
    Cytidine-5'-triphosphate-13C5
  • HY-W754236
    (R)-Carnitine Hydrochloride-13C3 98%
    (R)-Carnitine Hydrochloride-13C3 is the 13C-labeled L-Carnitine hydrochloride (HY-B2246). L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism.
    (R)-Carnitine Hydrochloride-13C3
  • HY-W755778
    3-Iodothyronamine hydrochloride-13C6 2724727-67-5 98%
    3-Iodothyronamine hydrochloride-13C6 is the 13C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure.
    3-Iodothyronamine hydrochloride-13C6
  • HY-W766574
    L-Glutamine-5-13C Hydrochloride 2714331-41-4 98%
    L-Glutamine-5-13C Hydrochloride is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-5-13C Hydrochloride
  • HY-W766709
    Desdiacetyl bisacodyl-d13 1285920-49-1 98%
    Desdiacetyl bisacodyl-d13 is the deuterium labeled Desacetyl bisacodyl (HY-131637). Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion.
    Desdiacetyl bisacodyl-d13
  • HY-W766829
    1-Linolenoyl-3-chloropropanediol-d5 2734920-69-3 98%
    1-Linolenoyl-3-chloropropanediol-d5 is the deuterium labeled 1-Linolenoyl-3-chloropropanediol (HY-W741075). 1-Linolenoyl-3-chloropropanediol is an ester product.
    1-Linolenoyl-3-chloropropanediol-d5
  • HY-W767186
    D-Mannoheptulose-13C7 98%
    D-Mannoheptulose-13C7 is the 13C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources.
    D-Mannoheptulose-13C7
  • HY-W768181
    1,5-Anhydrosorbitol-13C6 2751790-80-2 98%
    1,5-Anhydrosorbitol-13C6 (1,5-Anhydro-D-glucitol-13C6) is the 13C-labeled 1,5-Anhydrosorbitol (HY-113075). 1,5-Anhydrosorbitol is a short-term marker for glycemic control.
    1,5-Anhydrosorbitol-13C6
  • HY-W768213
    2'-Deoxyguanosine monohydrate-13C5 98%
    2'-Deoxyguanosine monohydrate-13C5 is the 13C-labeled 2'-Deoxyguanosine monohydrate (HY-D0185). 2'-Deoxyguanosine monohydrate is a nucleoside composed of guanine and deoxyribose, and is one of the basic building blocks of DNA. In the oxidation reaction mediated by singlet oxygen 1O2, the guanine base of 2'-Deoxyguanosine is easily oxidized to generate two major products, 4,8-dihydro-4-hydroxy-8-oxodG and 7,8-dihydro-8-oxodG. The oxidation products of 2'-Deoxyguanosine monohydrate may participate in DNA damage, which may affect gene expression or induce cancer.
    2'-Deoxyguanosine monohydrate-13C5
  • HY-W768220
    D-Fructose-1,2-13C2 98%
    D-Fructose-1,2-13C2 is the 13C-labeled D-Fructose. D-Fructose (D(-)-Fructose) is a monosaccharide found in honey, fruits, and?other?plants. Two D-Fructose molecules can combine to form a disaccharide, sucrose.
    D-Fructose-1,2-13C2
  • HY-W768246
    Galactose 1-phosphate-13C6 potassium 98%
    Galactose 1-phosphate-13C6 potassium is the 13C-labeled Galactose 1-phosphate Potassium salt (HY-113143A). Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars.
    Galactose 1-phosphate-13C6 potassium
Cat. No. Product Name / Synonyms Application Reactivity